Published works affiliated with MarkoLab

Hidden behavioral fingerprints in epilepsy

Gschwind T, Zeine A, Raikov I, Markowitz JE, Gillis WF, Felong S, Isom LL, Datta SR, Soltesz I.

Neuron June, 2023


Epilepsy is a major disorder affecting millions of people. Although modern electrophysiological and imaging approaches provide high-resolution access to the multi-scale brain circuit malfunctions in epilepsy, our understanding of how behavior changes with epilepsy has remained rudimentary. As a result, screening for new therapies for children and adults with devastating epilepsies still relies on the inherently subjective, semi-quantitative assessment of a handful of pre-selected behavioral signs of epilepsy in animal models. Here, we use machine learning-assisted 3D video analysis to reveal hidden behavioral phenotypes in mice with acquired and genetic epilepsies and track their alterations during post-insult epileptogenesis and in response to anti-epileptic drugs. These results show the persistent reconfiguration of behavioral fingerprints in epilepsy and indicate that they can be employed for rapid, automated anti-epileptic drug testing at scale.

Keywords: 3D video; behavior; biomarkers; drug screening; epilepsy; machine learning; phenotyping.

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.


Other Publications

Spontaneous behaviour is structured by reinforcement without explicit reward

Markowitz JE, Gillis WF, Jay M, Wood J, Harris RW, Cieszkowski R, Scott R, Brann D, Koveal D, Kula T, Weinreb C, Osman MAM, Pinto SR, Uchida N, Linderman SW, Sabatini BL, Datta SR.

Nature June, 2023

Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

Akiti K, Tsutsui-Kimura I, Xie Y, Mathis A, Markowitz JE, Anyoha R, Datta SR, Mathis MW, Uchida N, Watabe-Uchida M.

Neuron November, 2022

Distinguishing discrete and continuous behavioral variability using warped autoregressive HMMs

Costacurta J, Duncker L, Sheffer B, Gillis W, Weinreb C, Markowitz J, Datta S, Williams A, Linderman S.

Advances in Neural Information Processing Systems July, 2022

Flexible scaling and persistence of social vocal communication

Chen J, Markowitz JE, Lilascharoen V, Taylor S, Sheurpukdi P, Keller JA, Jensen JR, Lim BK, Datta SR, Stowers L.

Nature May, 2021